期刊
MOLECULAR BRAIN
卷 8, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s13041-015-0124-z
关键词
PAK1; Cerebral cortex; Neuronal migration; Cell proliferation; Cell cycle
资金
- Canadian Institutes of Health Research (CIHR) [MOP119421]
- Canadian Natural Science and Engineering Research Council (NSERC) [RGPIN341498]
- China National Basic Research Program (China 973 Program) [2012CB517903]
- Natural Science Foundation of China [NSFC 31200805]
- NSFC
- CIHR Joint Health Research Initiative Program [81161120543, CCI117959]
Background: p21-activated kinase 1 (PAK1) is a serine/threonine kinase known to be activated by the Rho family small GTPases and to play a key role in cytoskeletal reorganization, spine morphology and synaptic plasticity. PAK1 is also implicated in a number of neurodevelopmental and neurodegenerative diseases, including autism, intellectual disability and Alzheimer's disease. However, the role of PAK1 in early brain development remains unknown. Results: In this study, we employed genetic manipulations to investigate the role of PAK1 in the cerebral cortical development in mice. We showed that compared to the wild type littermates, PAK1 knockout mice have a reduction in the number of pyramidal neurons in several layers of the cerebral cortex, which is associated with a smaller pool of neural progenitor cells and impaired neuronal migration. Conclusion: These results suggest that PAK1 regulates cortical development by promoting the proliferation of neural progenitor cells and facilitating the migration of these neurons to specific regions of the cortex.
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