期刊
THIN SOLID FILMS
卷 519, 期 15, 页码 4658-4662出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.tsf.2011.01.012
关键词
Bioactive coating; Drug release behavior; Chitosan/calcium phosphate; Surface topography
类别
资金
- National Natural Science Foundation of China [50872122]
- Research Fund of the Doctoral Program of Higher Education of China [200703351015]
- Shenzhen Key Laboratory of Functional Polymers
Implants with antibiotic drug loaded bioactive coatings have been increasingly applied in orthopedic operations. Here we report the drug release behavior of gentamycin loaded chitosan/calcium phosphate coatings on titanium. Chitosan/calcium phosphate coatings with different component ratios and surface topographies were prepared by electrochemical deposition method. Our results showed that the drug release from these coatings was controlled by their component ratio and surface topography, and the former ratio played a more significant role. The present coatings could provide an effective way to create both good bioactivity and antibacterial activity. (C) 2011 Elsevier B.V. All rights reserved.
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