Thermal analysis of β-cyclodextrin/Berberine chloride inclusion compounds

Solid inclusion compounds of Berberine chloride (Berb) and beta-cyclodextrin (beta-CD) were prepared by grinding method and co-evaporation method. The formation and thermal characterization of solid inclusion compounds were investigated by Fourier transform-infrared (FT-IR) and differential scanning calorimetry (DSC). The results showed that the inclusion compounds of Berb and beta-CD could be prepared by the grinding method and co-evaporation method. DSC analysis afforded the quantitative evaluations of inclusion efficiency and showed that grinding method offered higher inclusion efficiency compared with co-evaporation method. Influence of grinding time on inclusion ratio of Berb with beta-CD was further studied by DSC measurement. DSC analysis could be considered as a rapid qualitative and quantitative analytical method in the preparation of cyclodextrins inclusion compounds. (c) 2009 Elsevier B.V. All rights reserved.