期刊
JOURNAL OF GINSENG RESEARCH
卷 39, 期 1, 页码 61-68出版社
KOREAN SOC GINSENG
DOI: 10.1016/j.jgr.2014.06.002
关键词
activating transcription factor 2; anti-inflammatory activity; interferon regulatory transcription factor 3; Korean red ginseng; protopanaxadiol saponin fraction
资金
- Korean Society of Ginseng
Background: Korean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and anti-inflammatory activities. Only a few studies have explored the molecular mechanism of KRG-mediated anti-inflammatory activity. Methods: We investigated the anti-inflammatory mechanisms of the protopanaxadiol saponin fraction (PPD-SF) of KRG using in vitro and in vivo inflammatory models. Results: PPD-SF dose-dependently diminished the release of inflammatory mediators [nitric oxide (NO), tumor necrosis factor-alpha, and prostaglandin E-2], and downregulated the mRNA expression of their corresponding genes (inducible NO synthase, tumor necrosis factor-alpha, and cyclooxygenase-2), without altering cell viability. The PPD-SF-mediated suppression of these events appeared to be regulated by a blockade of p38, c-Jun N-terminal kinase (JNK), and TANK (TRAF family member-associated NF-kappa-B activator)-binding kinase 1 (TBK1), which are linked to the activation of activating transcription factor 2 (ATF2) and interferon regulatory transcription factor 3 (IRF3). Moreover, this fraction also ameliorated HCl/ethanol/-induced gastritis via suppression of phospho-JNK2 levels. Conclusion: These results strongly suggest that the anti-inflammatory action of PPD-SF could be mediated by a reduction in the activation of p38-. JNK2-, and TANK-binding-kinase-l-linked pathways and their corresponding transcription factors (ATF2 and IRF3). Copyright (C) 2014, The Korean Society of Ginseng. Published by Elsevier. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据