期刊
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
卷 60, 期 2, 页码 2961-2965出版社
SOC CHILENA QUIMICA
DOI: 10.4067/S0717-97072015000200021
关键词
Synthesis; crystal structure; hydrazone compound; hydrogen bonding; antibacterial activity
资金
- Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJ1401025]
- Science and Technology of Wanzhou Science Committee [201403062]
- Youth Foundation of Three Georges University [13QN13]
A series of hydrazone compounds, 4-methyl-N'-(4-nitrobenzylidene)benzohydrazide methanol solvate (1), N'-(4-hydroxy-3-nitrobenzylidene)-4-methylbenzohydrazide dimethanol solvate (2), and N'-(3,5-dibromobenzylidene)-4-methylbenzohydrazide (3), derived from 4-methylbenzohydrazide with different benzaldehydes, were synthesized and characterized by physico-chemical methods and single crystal X-ray diffraction. Crystals of the compounds are stabilized by intermolecular hydrogen bonds, as well as pi center dot center dot center dot pi stacking interactions. Antibacterial activity of the compounds against Staphylococcus aureus, Escherichia coli, and Klebsielle pneumoniae strains was studied. Compounds 1 and 2 have moderate minimum inhibition concentration values on the tested bacteria strains. Compound 3, with the Br-substituent groups, showed the highest activity on the bacterial strains.
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