期刊
TEXTILE RESEARCH JOURNAL
卷 82, 期 17, 页码 1799-1805出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0040517511427968
关键词
Bombyx mori; silk fiber; gamma-ray; collagenase IA; degradation
资金
- National Natural Science Foundation of China [51075422, 51173125]
- Natural Science Foundation of Jiangsu Province of China [BK2009147, BK2010253]
- Society Development Foundation of Suzhou City of China [SYG201001]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Silk fibroin fiber from Bombyx mori has the advantages of superior tensile strength, non-toxicity, and good biocompatibility. However, its dense crystal structure makes implanted silk fibroin fiber resistant to biodegradation in the body. In the work described herein, silk fibroin fiber was treated with nine different dosages (0-3000 kGy) of Cobalt-60 (Co-60) gamma-rays, and the degradation performances of the irradiated silk fibroin fibers in collagenase IA (digestion for 30 days) were investigated. The results showed that the degradation leaching rate increased by 25, 35, and 58% at doses of 100, 200, and 500 kGy, respectively, and the diameter was about 62-65% compared with that in the control group. At a dose of 100 kGy, clear degradation stripes appeared on the surface of the silk fibroin fibers, and significantly increased at a dose of 200 kGy. With further increases of Co-60 dose, the stripes deepened and turned into cracks. Degradation increased in the amorphous regions of silk fibroin fiber after treatment with gamma-rays. With increasing doses of Co-60, degradation also occurred in crystalline areas and the silk II structure was partly converted into silk I. Our studies have shown that appropriate doses (such as 30-500 kGy) of gamma-ray pre-treatment on silk fibroin fiber can promote its biological degradation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据