期刊
TETRAHEDRON-ASYMMETRY
卷 24, 期 1, 页码 14-22出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2012.11.022
关键词
-
资金
- Scientific Research Commission of Mustafa Kemal University [04Y0127]
Chiral oxazolines have been synthesized from norephedrine and pyrrole nitrile or benzoyl chloride and applied to the catalytic asymmetric Henry reactions of p-nitro aldehydes with nitromethane to provide beta-hydroxy nitroalkanols in high conversion (up to 92%). The reaction was then optimized in terms of the metal, solvent, temperature, and amount of chiral ligand. The corresponding catalyst with Cu(OTf)(2) and isopropanol as the solvent gave the best enantioselectivities (up to 84% ee) of the corresponding beta-nitroalkanol for p-nitrobenzaldehyde. (C) 2012 Elsevier Ltd. All rights reserved.
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