期刊
TETRAHEDRON-ASYMMETRY
卷 24, 期 21-22, 页码 1395-1401出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2013.09.014
关键词
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资金
- Ministere de l'Enseignement Superieur et de la Recherche
- Ministere des Affaires Etrangeres (Eiffel Scholarship)
- Direction des Relations Internationales de l'Universite Paris Sud
- 'Groupement de Recherche Synthese et Procedes Durables pour une Chimie eco-Compatible' du CNRS
- Research Grant Program at the Lebanese University
- LabEx Charmmmat
Cobalt and chromium complexes have been prepared from chiral calix salen cyclic ligands. The corresponding tetrahydrosalen reduced forms have been used for copper salt complexation. These new chiral catalysts have been tested for their ability to promote asymmetric Henry reactions between various aldehydes and nitromethane under heterogeneous conditions. The best results were obtained by using tetrahydrosalen-based copper macrocycles, in terms of activity, selectivity, and stability during the recycling process. Ten consecutive runs could indeed be performed with the same catalyst batch to produce the target 1-(2-methoxy-phenyl)-2-nitro-ethanol with highly stable values in terms of yield and enantioselectivity (up to 94% ee). (C) 2013 Elsevier Ltd. All rights reserved.
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