期刊
TETRAHEDRON-ASYMMETRY
卷 22, 期 14-15, 页码 1490-1498出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2011.08.023
关键词
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资金
- Spanish government MICINN [CTQ2005-03416, CTQ2008-00683, CSD2006_0003]
- European Union [MEXC-CT-2005-0023600]
The use of C-2-symmetric enantiopure nitrogen ligands in the asymmetric catalytic alpha-fluorination of beta-ketoesters is described. SPANamine 1 in the presence of nickel salts gives up to 63% ee in the fluorination of tert-butyl 2-oxocyclopentanecarboxylate with N-fluorosuccinimide (NFSI). The same enantioselectivity is obtained when SPANamine 1 is used as an organocatalyst, although the reaction is much slower. (C) 2011 Elsevier Ltd. All rights reserved.
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