Proline-threonine dipeptide as an organocatalyst for the direct asymmetric aldol reaction

A new proline-threonine (H-Pro-Thr-OH) dipeptide has been demonstrated as an efficient organocatalyst for a direct asymmetric aldol reaction. It was found that this new peptide-based catalyst efficiently catalyzed the reaction between an aldehyde and acetone to provide beta-hydroxy ketones in good yields with good enantioselectivities. (c) 2009 Elsevier Ltd. All rights reserved.