Stereoselective synthesis of 2-azetidinylglycine and aminopyrrolidone derivatives from Garner's aldehyde

A new route to two hitherto unknown 2-azetidinylglycine derivatives and an aminopyrrolidone derivative has been developed which featured a diastereoselective conjugate addition of benzyl amine to an alpha,beta-unsaturated ester derived from Garner's aldehyde as the key step. (C) 2009 Elsevier Ltd. All rights reserved.