期刊
TETRAHEDRON-ASYMMETRY
卷 19, 期 17, 页码 2045-2050出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2008.08.018
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资金
- University of Pisa and Scuola Normale Superiore of Pisa
Different prolinamide and bis-prolinamide derivatives were checked as organocatalysts in the asymmetric Michael addition of cyclohexanone to aromatic nitroolefins, and the derivative bearing a D-prolinamide moiety linked at the 7-position emerged as the most efficient, giving the Michael adducts in satisfactory yield and ees of up to 95%. The corresponding system having a free CH group at the 3-position of the cholestanic backbone afforded the opposite enantiomer of the product, suggesting that the transition state is developed at the inner part of the cholestanic cavity, which is responsible for the substrate control determining the stereochemical outcome of the reaction. (C) 2008 Elsevier Ltd. All rights reserved.
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