Chiral N-thiophosphoryl imine-induced diastereoselective aza-Morita-Baylis-Hillman reaction

In the presence of an effective air-stable nucleophilic trialkylphosphine organocatalyst, 1,3,5-triaza-7-phosphaadamantane, a chiral N-thiophosphoryl imine bearing a (S)-binaphthalene skeleton induced a diastereoselective aza-MBH reaction with fair chemical yields and moderate to excellent diastereoselectivities (up to >99% de). (C) 2008 Elsevier Ltd. All rights reserved.