期刊
TETRAHEDRON LETTERS
卷 55, 期 17, 页码 2879-2882出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.03.094
关键词
C-H functionalization; N-Carbamoyl tetrahydroisoquinoline; Peroxydisulfate; Metal-free; Cross-dehydrogenative coupling
资金
- National Science Foundation of China [21202093]
- Young Scientist Foundation Grant of Shandong Province [BS2013YY001]
- Changjiang Scholars and Innovative Research Team [IRT13028]
A metal-free cross-dehydrogenative coupling of N-carbamoyl tetrahydroisoquinoline with a variety of C-H nucleophiles mediated by Na2S2O8 is developed. The reaction proceeds smoothly to give the coupled product in up to 83% yields. The nucleophile scope is broad, including simple ketones, aldehydes, and aryl rings. The carbamoyl protecting group can be readily removed under mild condition. The use of Na2S2O8 as the sole reagent for the CDC reaction is attractive based on economical and environmental factors. (C) 2014 Elsevier Ltd. All rights reserved.
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