期刊
TETRAHEDRON LETTERS
卷 55, 期 26, 页码 3615-3617出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.04.118
关键词
Nitrile hydration; Ruthenium; Phosphine; Amides
资金
- European Union and Hungary
- European Social Fund [TAMOP-4.2.2.A-11/1/KONV-2012-0043 (ENVIKUT)]
- National Research Fund of Hungary [OTKA 101372]
A simple and efficient synthesis of amides by selective hydration of aromatic and aliphatic nitriles is described. The catalysts are prepared in situ from easily available Ru-precursors and ligands using water as the solvent. The most active catalyst, is obtained from [RuCl2(dmso)(4)] and benzylated 1,3,5-triaza-7-phosphaadamantane. Of the 16 substrates examined, 92-99% conversions of 14 nitriles were achieved in one hour at reflux temperature. (C) 2014 Elsevier Ltd. All rights reserved.
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