期刊
TETRAHEDRON LETTERS
卷 55, 期 36, 页码 5062-5065出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.07.032
关键词
Biocatalysis; Enzymatic kinetic resolution; Chiral chlorohydrins; Silk fibroin; Pseudomonas fluorescens
资金
- CNPq
- FAPESP
- CAPES
Aromatic, allylic, and aliphatic compounds containing a chlorohydrin group were selected as substrates for the enzymatic kinetic resolution mediated by Amano AK lipase from Pseudomonas fluorescens immobilized in silk friboin-alginate spheres. Thus, the enantioselectivity of the process was sufficient for the production of the desired alcohols and acetates in good yields and high enantiomeric purities. This Letter provides a simple, cheap, and practical protocol for enantioselective synthesis of chlorohydrins and reinforces the versatility of silk fibroin as supports for heterogeneous catalysts. (C) 2014 Elsevier Ltd. All rights reserved.
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