期刊
TETRAHEDRON LETTERS
卷 55, 期 45, 页码 6212-6215出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.09.065
关键词
Coelenterazine; Imidazo[1,2-a]pyridine; Benzylglyoxals; Antioxidant; 2,2-Diphenyl-1-picrylhydrazyl
资金
- University of Wollongong
A convenient and highly convergent method for the synthesis of new imidazo[1,2-a]pyridine-based coelenterazine analogues is reported. The imidazo[1,2-a]pyridine core was constructed through a condensation between 2-aminopyridine analogues and arylglyoxals. Additionally, a new approach to the synthesis of benzylglyoxals was introduced. The imidazo[1,2-a]pyridines display moderate antioxidant activities at a low micromolar level in 2,2-diphenyl-1-picrylhydrazyl (DPPH). Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.
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