期刊
TETRAHEDRON LETTERS
卷 55, 期 30, 页码 4126-4128出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.05.099
关键词
Maedamide; Marine cyanobacteria; Depsipeptide; Chymotrypsin inhibitor; Lyngbya
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [24310160, 25750386]
- MEXT from the Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [25750386] Funding Source: KAKEN
Maedamide, a novel chymotrypsin-inhibiting depsipeptide, was isolated from a cyanobacterial assemblage that mostly consisted of Lyngbya sp. Its structure was elucidated by spectroscopic analyses and chiral HPLC analyses of hydrolysis products. Maedamide selectively inhibited chymotrypsin but not elastase and trypsin. In addition, Maedamide strongly inhibited the growth of HeLa cells and HL60 cells. (C) 2014 Elsevier Ltd. All rights reserved.
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