期刊
TETRAHEDRON LETTERS
卷 55, 期 52, 页码 7156-7166出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.11.060
关键词
Chiral acyclic nucleoside; Nucleosides; Nucleoside phosphonates; Chiral pool; Asymmetric catalysis
资金
- National Natural Science Foundation of China [21172059, 21272059, 21202039, 21372066, 21472037, 21402041]
- Innovative Research Team from the University of Henan Province [2012IRTSTHN006]
- Doctoral Program of Higher Education of China [20124104110006]
- Program for Science & Technology Innovation Talents in Universities of Henan Province [13HASTIT013]
- Foundation for University Young Key Teacher by Henan Province of China [2011GGJS-132]
Acyclic nucleosides and their phosphonates possess significantly antiviral and cytostatic activities. For acyclic nucleosides and their phosphonates, the introduction of a chiral group to their side chain or the absolute configuration of the chiral atom could affect their biological activities obviously. Thus, the asymmetric synthesis of chiral acyclic nucleosides and their phosphonates has received continuous attention. The previous reports mainly focus on employing the chiral pool and chiral auxiliary methods for the synthesis of chiral acyclic nucleosides and their phosphonates. In contrast, the asymmetric catalysis methods for the synthesis of acyclic nucleosides and their phosphonates are still in the beginning. This digest paper will serve to highlight the significant progress that has been made in these areas. (C) 2014 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
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