FeCl3 catalyzed sp3 C-H amination: synthesis of aminals with arylamines and amides

A simple and efficient amination of sp(3) C-H bonds adjacent to a nitrogen atom in amides was introduced. The reaction was catalyzed by cheap and low toxic iron salt and used arylamines as nitrogen source. It provides a straightforward construction of acyclic aminals under mild conditions. (C) 2014 Published by Elsevier Ltd.