An efficient 'on-water' synthesis of 1,4-dihydropyridines using Fe3O4@SiO2 nanoparticles as a reusable catalyst

An 'on-water', efficient, high yielding, expeditious method has been developed for the synthesis of 1,4-dihydropyridine (1,4-DHP) derivatives via an one-pot multi-component condensation of dimedone or 4-hydroxycoumarine, aldehydes, and ammonium acetate using Fe3O4@SiO2 nanoparticles as a recyclable heterogeneous catalyst. This method takes advantage of the fact that water, a green solvent is used in combination with Fe3O4@SiO2 nanoparticles as catalyst which can be easily recovered magnetically and reused for further runs. (C) 2014 Elsevier Ltd. All rights reserved.