期刊
TETRAHEDRON LETTERS
卷 55, 期 31, 页码 4295-4297出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.04.084
关键词
Honokiol; Kumada coupling; Tetrakis(triphenylphosphine)palladium; Demethylation
资金
- CSIR-New Delhi
- 12th FYP DENOVA [CSCO205]
A concise four-step efficient synthesis of honokiol 1 in 68% overall yield is described here. The present method involves tetrakis(triphenylphosphine)palladium [Pd(Ph-3)(4)] catalyzed Kumada coupling in two key steps. First coupling generates biaryl backbone intermediate 5 and second generates 2,4'-O-dimethylhonokiol 3. Final demethylation under AlCl3/DMS condition affords honokiol in quantitative yield. (C) 2014 Elsevier Ltd. All rights reserved.
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