期刊
TETRAHEDRON LETTERS
卷 55, 期 2, 页码 346-350出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.11.027
关键词
Chiral N-heterocyclic carbene; Hydroxyalkyl-imidazolium salt; Mizoroki-Heck reaction; MgO nanoparticles; Asymmetric addition
资金
- Research Council of Shahid Beheshti University
A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions. (C) 2013 Elsevier Ltd. All rights reserved.
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