Briarenolide J, the first 12-chlorobriarane diterpenoid from an octocoral Briareum sp. (Briareidae)

A novel 6,12-dichlorobriarane diterpenoid, briarenolide J (1), was isolated from an octocoral identified as Briareum sp. The structure of briarane 1 was elucidated by spectroscopic methods. Briarenolide J (1) is the first metabolite of a briarane-related natural product found to possess a chlorine atom at C-12 and this compound was found to display inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils with IC50 values of 14.98 and 9.96 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.