期刊
TETRAHEDRON LETTERS
卷 55, 期 8, 页码 1461-1463出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2014.01.048
关键词
RNA; G-quadruplex; Oligonucleotide; Fluorophore; Intermolecular
资金
- Ministry of Education, Science and Technology (MEST)
We synthesized a fluorescent adenosine derivative, rA(PY), as a probe to study RNA structural transitions, in particular the intermolecular G-quadruplex formation. rA(PY) was incorporated into the dangling positions of guanine-rich oligonucleotides, which under physiological conditions undergo pi-stacking on top of each other exhibiting a strong emission signal in their G-quadruplex conformation, but not in their single-stranded state. (C) 2014 Elsevier Ltd. All rights reserved.
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