Tandyukisin, a novel ketoaldehyde decalin derivative, produced by a marine sponge-derived Trichoderrna harzianum

Tandyukisin (1), a novel decalin derivative with an enolic p-ketoaldehyde, has been isolated from a strain of Trichoderma hmzianum OUPS-111D-4 originally derived from the marine sponge Halichondria okadai, and its structure has been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques. In addition, the absolute configuration for 1 was established by the application of CD spectrum to the tribenzoate derivative. This compounds exhibited moderate cytotoxicity against human cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.