期刊
TETRAHEDRON LETTERS
卷 54, 期 52, 页码 7188-7192出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.10.113
关键词
Polyphenols; Synthesis; Natural product; Anticancer agents
资金
- Ministry of Education, Science, Culture, Sports, and Technology of Japan [22570112]
- Uehara Memorial Foundation
- Shinshu Foundation for Promotion of Agricultural and Forest Science
- Grants-in-Aid for Scientific Research [22570112] Funding Source: KAKEN
Total synthesis of prodelphinidin B1, B2, and B4 has been accomplished. The key step is Lewis acid-mediated equimolar condensations between an epigallocatechin and/or a gallocatechin nucleophile and an epigallocatechin and/or a gallocatechin electrophile. The antitumor effects of synthetic prodelphinidin B1-B4 against human PC-3 prostate cancer cell lines have been investigated. These compounds showed significant antitumor effects. Their activity seemed to be little bit stronger than EGCG and prodelphinidin B3, known antitumor agent. (C) 2013 Elsevier Ltd. All rights reserved.
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