期刊
TETRAHEDRON LETTERS
卷 54, 期 45, 页码 6090-6093出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.08.119
关键词
Enzymatic resolution; Dry mycelia; Flow reactor; Flurbiprofen; Aspergillus oryzae
Cell-bound lipases of dry mycelium of Aspergillus oryzae were used in organic solvent for the resolution of racemic flurbiprofen by direct esterification with ethanol in a flow-chemistry reactor. Under flow conditions a significant reduction of the reaction time and an increase of the enantioselectivity were achieved compared to the batch mode. Moreover, the process was implemented by adding an in-line purification step integrated with the racemization of the unreacted flurbiprofen directly into a polymer-supported resin. (C) 2013 Elsevier Ltd. All rights reserved.
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