期刊
TETRAHEDRON LETTERS
卷 54, 期 49, 页码 6695-6699出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.09.060
关键词
Saccharonol B; Saccharomonospora azurea; Cytotoxic; Actinomycete; Antimicrobial; Isocoumarin
资金
- ICMR, New Delhi
- CSIR 12th FYP project [ITR-0001]
From an antimicrobial gram-positive actinomycete strain of Saccharomonospora azurea (MTCC11714) isolated from high altitude soil of Kargil (J&K, India), a new isocoumarin saccharonol B (2) along with two known compounds viz. saccharonol A (1) and piericidin A(3) (3) was isolated and characterized. The structure of the new compound was established based on extensive 2D-NMR data. Saccharonol B (2) exhibited mild antimicrobial activity against a standard panel of microorganisms Staphylococcus aureus ATCC 29213, Candida albicans ATCC 90028, and Aspergillus fumigatus MTCC 1811 with MIC values in the range of 128-248 mu g/mL. Saccharonol B (2) and piericidin A(3) (3) showed selective cytotoxic activity against human pancreatic carcinoma cell line (MIAPaCa-2) with IC50 values of 9 and 8 mu M, respectively. Mechanistic studies indicated that saccharonol B (2) arrests S-phase of the cell cycle and causes dose-dependent loss of mitochondrial potential in MIAPaCa-2 cells. (C) 2013 Elsevier Ltd. All rights reserved.
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