期刊
TETRAHEDRON LETTERS
卷 54, 期 50, 页码 6826-6828出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.10.003
关键词
Natural products; Cyclic peptide; Isolation and structure; Inhibition of nitric oxide production
资金
- JSPS [25702047, 23102014, 23310148]
- Naito Foundation
- Uehara Memorial Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [23102014, 25702047, 23310148] Funding Source: KAKEN
A new cyclic heptapeptide, stylissatin A (1), was isolated from the Papua New Guinean marine sponge Stylissa massa. Through the use of 1D and 2D NMR spectroscopic analysis, Marfey's method, and MS/MS analysis, its structure was determined to be cyclo-[Tyr(1)-Ile(2)-Phe(3)-Pro(4)-Ile(5)-Pro(6)-Phe(7)]. Stylissatin A inhibited nitric oxide production in LPS-stimulated murine macrophage RAW264.7 cells with an IC50 value of 87 mu M. (C) 2013 Elsevier Ltd. All rights reserved.
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