Palladium-catalyzed asymmetric hydrogenation of dibenzo[b,f][1,4]thiazepines activated by Bronsted acid

An efficient and facile route to chiral dihydrodibenzothiazepines has been successfully developed via palladium-catalyzed asymmetric hydrogenation of the dibenzothiazepines with Bronsted acid as activator with up to 94% ee. (C) 2013 Elsevier Ltd. All rights reserved.