期刊
TETRAHEDRON LETTERS
卷 54, 期 41, 页码 5558-5561出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.07.107
关键词
Sialic acid; Microwave; de-N-acetylation; N-Glycolylneuraminic; alpha-2,8-Polysialic acid
资金
- Griffith University
- Institute for Glycomics
- Australian Research Council
- National Health and Medical Research Council
A rapid, efficient and scalable synthesis of biologically-relevant N-glycolylneuraminic acid derivatives from the natural N-acetyl (Neu5Ac) precursors has been developed. Microwave irradiation provides accelerated de-N-acetylation compared to more traditional methods, with optimised NaOH-promoted de-N-acetylation in only 15 min. The prepared amines were readily re-N-acylated to afford the corresponding N-glycolyl (Neu5Gc) analogues. (C) 2013 Elsevier Ltd. All rights reserved.
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