Toward waste-free peptide synthesis using ionic reagents and ionic liquids as solvents

CBEIT 1, an ionic coupling reagent, gives access to amino acid carbamates, and allows waste-free peptide coupling. The only by-products are carbon dioxide and ethylimidazolium triflate that is an ionic liquid playing the role of the solvent. (c) 2013 Elsevier Ltd. All rights reserved.