期刊
TETRAHEDRON LETTERS
卷 54, 期 19, 页码 2340-2343出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.02.055
关键词
Three-component Ugi reaction; MCR; Amide; Amidine; p-Toluenesulfinic acid
资金
- College of Pharmacy, the University of Arizona
A mild, cost-effective, and simple three-component Ugi-type reaction using p-toluenesulfinic acid (pTSIA) as the acid catalyst has been developed to synthesize alpha-amino amides and alpha-amino amidines. Employing 1 equiv of amine used in the reaction generated alpha-amino amides exclusively, while 2 equiv of amines, especially with more nucleophilic aniline such as p-anisidine, yielded the alpha-amino amidines as the major product. This methodology would be suitable for the synthesis of natural or unnatural amino acids and drug-like amidine analogues. Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据