4.4 Article

Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

期刊

TETRAHEDRON LETTERS
卷 54, 期 45, 页码 6081-6083

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2013.08.137

关键词

Marine-derived fungus; Aspergillus sydowii; Mycobacterium tuberculosis; Protein tyrosine phosphatase A (PtpA)

资金

  1. National Program on Key Basic Research Project (973 program) [2013CB734000, 2012CB721000]
  2. National Natural Science Foundation of China [30901849, 81102356, 81102369]
  3. CAS Pillar Program [XDA04074000]
  4. Ministry of Science and Technology of China [2011ZX11102011-11]
  5. Genzyme, a Sanofi company
  6. Institute for Molecular Bioscience
  7. University of Queensland
  8. Australian Research Council [LP120100088]
  9. Canadian Institute of Health Research China Canada research program
  10. ational Distinguished Young Scholar Program in China

向作者/读者索取更多资源

Chemical analysis of an East China Sea marine-derived fungus, Aspergillus sydowii (MF357) returned three new tris-pyrogallol ethers, sydowiols A-C (1-3), and two known bis-pyrogallol ethers, violaceols I (4) and 11 (5). Structures were assigned on the basis of detailed spectroscopic analysis and by consideration of symmetry. Sydowiols A (1) and C (3) were responsible for the inhibitory activity detected in the crude fungal extract against Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA). (C) 2013 Elsevier Ltd. All rights reserved.

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