期刊
TETRAHEDRON LETTERS
卷 54, 期 10, 页码 1189-1191出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.12.038
关键词
Biotransformation; Endophytic fungus; Naphthalenone pentaketide; Secondary metabolites; Circular dichroism
资金
- Fondation pour la Recherche sur la Biodiversite [AAP-IN-2009-026]
- Action Transversale du Museum 'Biodiversite des microorganismes dans les ecosystemes actuels et passes' from the Museum national d'Histoire naturelle
We describe here a direct access to (4S)-isosclerone (+)-1, an important structural component of several natural products featuring a spirobisnaphthalene ring system. Starting with the commercially available 5-hydroxy-1,4-naphthalenedione (juglone), biotransformation by the isosclerone-producing endophytic fungus Paraconiothyrium variabile is described. The absolute configuration of (+)-1 was determined unambiguously using circular dichroism and by measurement of the optical rotation. Moreover, the bio-transformations of other naphthalene derivatives were undertaken and led to the corresponding (4S)-hydroxy-l-tetralone. At last, this work brings some insights on the biosynthesis of natural tetralones. (C) 2012 Elsevier Ltd. All rights reserved.
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