期刊
TETRAHEDRON LETTERS
卷 54, 期 8, 页码 749-752出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.11.032
关键词
alpha-Amino acid; alpha-Aminonitrile; Asymmetric synthesis; Quinoline; Strecker reaction
资金
- MESRS (Ministere de l'Enseignement Superieur et de la Recherche Scientifique) Algeria
This study describes the synthesis of novel alpha-aminonitrile derivatives possessing a quinoline subunit via a Strecker reaction. Chiral alpha-methylbenzylamines were used to carry out the diastereoselective version of this sequence. Conversion of an enantiopure 2-chloroquinolin-3-yl derivative into the corresponding alpha-aminoester resulted in the concomitant formation of a 2(1H)-quinolinone moiety and a partial racemization. Single crystal X-ray structures are reported for three compounds. (C) 2012 Elsevier Ltd. All rights reserved.
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