期刊
TETRAHEDRON LETTERS
卷 54, 期 6, 页码 584-586出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.11.094
关键词
Brassinosteroids; Thioacetal-containing chiral synthon; Side chain construction
资金
- Belorussian Foundation for Fundamental Research [X12P-169]
A new approach to steroidal derivatives of the campestane series, containing the 22 alpha-hydroxy-, 22 alpha,23 alpha-dihydroxy-, and 22 alpha-hydroxy-23-ketone moieties characteristic of brassinolide and its congeners, has been developed. The key step is the coupling of a steroidal C-22 aldehyde with an anion derived from a specially synthesized thioacetal-containing chiral synthon. The cathasterone and cryptolide side chains are prepared by reductive or hydrolytic thioketal removal, respectively. The brassinolide side chain is obtained by DIBAL-H reduction of the TBS-protected 22 alpha-hydroxy-23-ketone. (c) 2012 Elsevier Ltd. All rights reserved.
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