期刊
TETRAHEDRON LETTERS
卷 54, 期 8, 页码 883-886出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.11.123
关键词
Ochratoxin alpha synthesis; Analytical standard; Ochratoxin A (OTA); Directed ortho-metalation; Metalation of unprotected benzoic acids
资金
- Brazilian National Council for Scientific and Technological Development (CNPq)
Two new routes for the synthesis of enantiomerically pure ochratoxin alpha ((3R)-OT alpha) are presented, which is the key intermediate for the synthesis of ochratoxin A (OTA) by coupling reaction with the amino acid (L)-phenylalanine. The key step of both routes is the one pot directed ortho-metalation/alkylation/lactonization of unprotected and suitably functionalized aromatic carboxylic acids, using lithium tetramethylpiperidide (LIMP) and (R)-propylene oxide. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据