Concise total syntheses of Marinoquinolines A-C

The first concise total syntheses of pyrroloquinoline natural products, Marinoquinolines A-C, have been achieved in six linear steps from commercially available starting materials. The key steps were a reaction between (p-tolylsulfonyl)methylisocyanide (TosMIC) and alpha, beta-unsaturated ester under basic condition to prepare the pyrrole moiety and Morgen-Walls reaction to construct quinoline ring. (C) 2012 Elsevier Ltd. All rights reserved.