期刊
TETRAHEDRON LETTERS
卷 53, 期 9, 页码 1071-1074出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.12.089
关键词
Biocatalysis; Pictet-Spengler reaction; Norcoclaurine synthase; Tetrahydroisoquinoline alkaloids
资金
- Karlsruhe House of Young Scientists (KHYS)
- BBSRC [BBS/E/J/000CA489] Funding Source: UKRI
- EPSRC [EP/J012947/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000CA489] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/J012947/1] Funding Source: researchfish
The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet-Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
