期刊
TETRAHEDRON LETTERS
卷 53, 期 3, 页码 275-276出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.11.029
关键词
LCZ696; Hypertension; X-ray crystallography; ARNI; Supramolecular complex
LCZ696 displays several surprising features, such as an intrinsic stabilization of the supramolecular complex by monovalent multi-coordinated sodium cations and water molecules. In addition, to the best of our knowledge, the compound is the first example of a dual-acting pharmaceutical built as a supramolecular complex delivering two pharmacologic effects angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition. (C) 2011 Elsevier Ltd. All rights reserved.
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