期刊
TETRAHEDRON LETTERS
卷 53, 期 3, 页码 277-280出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2011.10.013
关键词
Entomopathogenic fungi; Secondary metabolites; Polyketides; DNA methyltransferase inhibitor; Epigenetics
资金
- Ministry of Education, Science, Sports and Culture of Japan [23710248, 23590582]
- Japan Science and Technology Agency (JST) [AS221Z01739G]
- Uehara Memorial Foundation
- Japan Association for Chemical Innovation
- Grants-in-Aid for Scientific Research [23710248, 23651212, 23590582] Funding Source: KAKEN
A new aromatic polyketide glycoside, indigotide A (1), was isolated from the culture broth of the entomopathogenic fungus, Cordyceps indigotica, along with known cyclic depsipeptides, destruxins A, A(2), B, B-2 and E (3-7), and a polyketide, NG-393 (8). Repeated treatment of the C. indigotica culture broth with 5-azacytidine, a DNA methyltransferase inhibitor, led to the isolation of another new aromatic polyketide glycoside, indigotide B (2). (C) 2011 Elsevier Ltd. All rights reserved.
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