期刊
TETRAHEDRON LETTERS
卷 53, 期 32, 页码 4248-4252出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.06.023
关键词
2-Alkynoic acid; 2-Iodotrifluoroacetanilide; Decarboxylative cross-coupling; Domino reaction; Copper mediated reactions
The efficient synthesis of 2-arylindoles and 6H-isoindolo[2,1-a]indol-6-one through copper catalysed domino sp-sp(2) decarboxylative cross-coupling and subsequent cyclisation reactions of arylpropiolic acids with 2-iodotrifluoroacetanilide has been described. This methodology also demonstrates that indolo[1,2-c]quinazolin-6(5H)-one can be obtained with the elimination of trifluoromethyl anion. (C) 2012 Elsevier Ltd. All rights reserved.
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