期刊
TETRAHEDRON LETTERS
卷 53, 期 23, 页码 2842-2846出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.03.114
关键词
Streptomyces hygroscopicus; Marine fish; Halichoblelide; 16-Membered ring macrolide; Cytotoxic activity
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [23590028] Funding Source: KAKEN
Halichoblelide B (1) and C (2), novel macrolides with potent cytotoxicity against tumor cells in culture, have been isolated from a strain of Streptomyces hygroscopicus originally derived from the marine fish Halichoeres bleekeri, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and chemical transformations. These compounds exhibited significant cytotoxicity against human cancer cell lines. (C) 2012 Elsevier Ltd. All rights reserved.
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