The stereoselective total synthesis of (3R,5R)-sonnerlactone and (3R,5S)-sonnerlactone

The stereoselective synthesis of (3R,5R)-sonnerlactone (1) and (3R,55)-sonnerlactone (2) has been accomplished starting from L-aspartic acid. Our strategy involves asymmetric allylation, Alder-Rickert reaction and Mitsunobu macrolactonization as the key steps. (C) 2012 Elsevier Ltd. All rights reserved.