Preparation of tertiary amides via aryl, heteroaryl, and benzyl organozinc reagents; scope and limitations

A facile synthetic protocol for the preparation of tertiary amides has been developed. The title compounds have been successfully obtained by the Pd-catalyzed cross-coupling reactions of readily available aryl and benzyl organozinc reagents with the appropriate carbamoyl chlorides. (C) 2012 Elsevier Ltd. All rights reserved.