期刊
TETRAHEDRON LETTERS
卷 53, 期 26, 页码 3353-3356出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.04.090
关键词
Ugi reactions; Indoloketopiperazines; Isocyanides
资金
- University of Tehran
2-(3-Chloro-2-formyl-1H-indol-1-yl) acetic acid, as a bifunctional formyl-acid, is prepared in three steps. This compound undergoes a one-pot, four-center, three-component Ugi reaction with primary amines and alkyl isocyanides. A series of novel substituted indoloketopiperazine derivatives are obtained in moderate to high yields. (C) 2012 Elsevier Ltd. All rights reserved.
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