期刊
TETRAHEDRON LETTERS
卷 53, 期 24, 页码 3104-3107出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.04.034
关键词
Cyclic glycopeptidomimetic; Pot-amino alkyl isonitrile; Ugi multi-component reaction; Click chemistry
资金
- Department of Science and Technology, Government of India, New Delhi [SR/S1/OC-52/2011]
Sequential combination of Ugi-MCR and click chemistry has been employed for the synthesis of triazole linked cyclic glycopeptidomimetics. The protocol employs Poc-amino alkyl isonitriles, sugar-1-amines, azido acids, and simple aldehydes as precursors. The dual nature of the propargyloxycarbonyl (Poc) group was explored for amine protection as well as cycloaddition with an azide. All the cyclic glycopeptidomimetics are isolated and characterized. (C) 2012 Elsevier Ltd. All rights reserved.
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