Catalyst-free, facile, and an efficient synthesis of α-aminonitriles employing Zn(CN)2 as an ecofriendly cyanating agent

An efficient and eco-friendly method has been developed for the synthesis of alpha-aminonitriles via one-pot three-component condensation of carbonyl compounds, amines, and Zn(CN)(2) under mild conditions. This protocol has the features of use of inexpensive, ecofriendly readily available, effective cyanide source, high yield, and simple work-up procedure. (C) 2011 Elsevier Ltd. All rights reserved.